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  • Title: [Effect of amniotic fluid on the "spontaneous" transformation of embryonic cells of rats].
    Author: Eroshkina AM.
    Journal: Vopr Onkol; 1977; 23(5):79-86. PubMed ID: 888421.
    Abstract:
    While applying amniotic fluid of cow embryos, as one of the components of nutrition medium, the tumor-producing ability of cells is manifested in later period of cultivation. Less malignancy of the transformed cultures was noted, that is supported by a more slow tumor development, by nearly complete absence of metastases, and longer survival of tumor-bearing animals. On the other hand, amniotic fluid renders a somewhat accelerating (2--3 times greater than in the control) effect on the impairment of cultures diploidy. Heteroploidization of the cultures proceeds largely on account of chromosome number shifts from diploid to near-tetraploid amount. Thus, amniotic liquor inhibits the process of "spontaneous" malignant transformation of embryonal cells in prolonged cultivation, simultaneously accelerating the impairment of culture diploidy.
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