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  • Title: Lack of voltage-operated calcium channel in rat glioma C6 cells.
    Author: Imoto K, Takemura H, Kaneko M, Ohshika H.
    Journal: Res Commun Mol Pathol Pharmacol; 1996 Aug; 93(2):249-56. PubMed ID: 8884995.
    Abstract:
    We examined whether rat glioma C6 cells have voltage-operated Ca2+ channel (VOC) or not. The addition of high K+ did not affect the cytoplasmic Ca2+ concentration ([Ca2+]i). In addition, BAY K 8644, a VOC against, did not increase [Ca2+]i even in the presence of high K+. Bombesin (BBS), an inositol trisphosphate-generating drug, and thapsigargin (TG), a microsomal Ca(2+)-ATPase inhibitor, increased [Ca2+]i, after which it decreased to a sustained, and still higher than original level. The addition of verapamil, diltiazem and nimodipine did not affect an increase in [Ca2+]i induced by BBS and TG. The addition of SK&F 96365, a receptor-operated Ca2+ channel (ROC) blocker, reduced the sustained increase in [Ca2+]i induced by BBS and TG. The present results suggest that VOC does not exist in rat glioma C6 cells and this cell line is a good model for investigating signal transduction via ROC as glial cells.
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