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  • Title: [Ticlopidine-induced neutropenia].
    Author: Balbir A, Odeh M, Atias D, Oliven A.
    Journal: Harefuah; 1996 Jun 16; 130(12):822-4, 879. PubMed ID: 8885506.
    Abstract:
    Ticlopidine (TCP) is a drug that inhibits platelet aggregation. Several studies have demonstrated its superiority over aspirin in preventing stroke and other thromboembolic diseases. However, neutropenia occurs in about 2% of TCP-treated patients, which therefore may advance to agranulocytosis, sepsis and death. They should be carefully followed with blood counts. We report 2 patients hospitalized with severe neutropenia while on TCP, despite having had regular blood counts. Their complications underline the need for patient selection and meticulous follow-up when ticlopidine is prescribed.
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