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  • Title: In vivo regulation of the IL-1 beta system (ligand, receptors I and II, receptor accessory protein, and receptor antagonist) and TNF-alpha mRNAs in specific brain regions.
    Author: Ilyin SE, Plata-Salamán CR.
    Journal: Biochem Biophys Res Commun; 1996 Oct 23; 227(3):861-7. PubMed ID: 8886022.
    Abstract:
    Interleukin-1 beta (IL-1 beta) acts directly in the central nervous system (CNS). Here, using a novel behavioral-molecular approach, we report the regulation of the complete II-1 beta system (ligand, receptors, receptor accessory protein, and receptor antagonist) and TNF-alpha mRNAs in the CNS in response to the chronic intracerebroventricular microinfusion of IL-1 beta. IL-1 beta increased the IL-1 beta system and TNF-alpha mRNAs in the cerebellum and parieto-frontal cortex. IL 1 beta-induced profiles of IL-1 beta, IL-1 receptor type I and II (IL-1RI and IL-1RII), and IL-1 receptor antagonist (II-1Ra) mRNAs were highly intercorrelated in the same samples. The data suggest the operation of an IL-1 beta feedback system (IL-1 beta/IL-1RI/IL-1RII/IL-1Ra) within a brain region. The fine regulation of the CNS IL-1 beta system may depend on a balance between the ligand (IL-1 beta) action on the IL-1RI and the induction of inhibitory mechanisms (IL-1RII and IL-1Ra). This may have implications regarding neurological diseases associated with high levels of IL-1 beta in the brain.
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