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  • Title: Changes in spleen and thymus cell phenotypes in mice vaccinated with the Coxiella burnetii phase I whole-cell vaccine or the chloroform-methanol residue subunit vaccine.
    Author: Waag DM, Williams JC.
    Journal: Acta Virol; 1996 Apr; 40(2):87-94. PubMed ID: 8886117.
    Abstract:
    Lymphoid cell phenotypes within the spleen and thymus were analyzed to determine whether numerical or proportional changes in cell populations could account for the immunosuppression seen after vaccination of mice with inactivated phase I Coxiella burnetii whole-cell vaccine (WCI). Within 21 days of vaccination with WCI, there was a reduction in the percentage of splenic T cells and B cells while the numbers of thymic T cells and B cells increased. A substantial percentage of spleen cells did not bear typical T cell or B cell surface markers. In contrast, except for an early rise (by day 3) in the numbers of T and B cells, injecting the chloroform-methanol residue subunit-vaccine (CMR) caused no significant phenotypic changes of lymphoid cells in the spleen or thymus. The percentage of thymus cells bearing T cell phenotypes was similar in mice vaccinated with WCI or CMR. However, the total number of T cells in the thymus dramatically decreased in mice vaccinated with WCI. There was no correlation between the lymphocyte hyporesponsiveness to mitogens and WCI in vitro and the increased numbers of CD8-positive splenocytes. These results suggest that WCI vaccination caused dramatic changes in splenocyte and thymocyte lymphocyte populations and provide evidence for the more benign nature of the CMR vaccine.
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