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  • Title: Molecular mechanisms in the regulation of renal proximal tubular Na/phosphate cotransport.
    Author: Murer H, Lötscher M, Kaissling B, Biber J.
    Journal: Kidney Blood Press Res; 1996; 19(3-4):151-4. PubMed ID: 8887250.
    Abstract:
    Renal proximal tubular Na/phosphate cotransport is the key target in the control of renal phosphate handling. Using molecular tools for the type II Na/phosphate cotransporter, it could be documented that altered brush border membrane phosphate transport reflects a state of altered brush border expression of the specific transporter molecule. This alteration is either the consequence of specific membrane insertion/retrieval processes and/or reflects states of altered synthesisdegradation of the transporter.
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