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  • Title: Normal and abnormal pulmonary ventilation: visualization at hyperpolarized He-3 MR imaging.
    Author: Kauczor HU, Hofmann D, Kreitner KF, Nilgens H, Surkau R, Heil W, Potthast A, Knopp MV, Otten EW, Thelen M.
    Journal: Radiology; 1996 Nov; 201(2):564-8. PubMed ID: 8888259.
    Abstract:
    To assess the feasibility of helium-3 magnetic resonance (MR) imaging with a three-dimensional fast low-angle shot (FLASH) sequence, He-3 gas (volume, 300 mL; pressure, 3 x 10(5) Pa; polarized up to 45% by means of optimal pumping) was inhaled by five healthy volunteers and five patients with pulmonary diseases. All breath-hold examinations (22-42 seconds) were completed successfully. Normal ventilation was depicted with homogeneous high signal intensity, lesions were depicted as causing defects, and obstructive lung disease was depicted with severely inhomogeneous signal intensity.
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