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  • Title: Sensitization to the locomotor activating effects of cocaine following cocaethylene-preexposure.
    Author: Horger BA, Taylor JR, Elsworth JD, Jatlow PI, Roth RH.
    Journal: Brain Res; 1996 Sep 09; 733(1):133-7. PubMed ID: 8891259.
    Abstract:
    The present study assessed the ability of cocaethylene to induce sensitization to the behavioral activating effects of cocaine in the male Sprague-Dawley rat. Preexposure to cocaethylene (15 or 25 mg/kg) significantly enhanced the locomotor activating effects of a subsequent cocaine (15 mg/kg) challenge injection. In addition, acute intraperitonecal administration at several doses (10, 15, or 25 mg/kg) confirmed previous reports of increased bioavailability of cocaine in brain and plasma relative to cocaethylene. These data are discussed in terms of previous work in which a significant augmentation of cocaine-induced locomotor activity was not observed following cocaethylene preexposure.
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