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  • Title: Biphasic and dose-dependent accumulation of INSP3 in Trypanosoma cruzi stimulated by a synthetic peptide carrying a chicken alpha D-globin fragment.
    Author: Garrido MN, Bollo MI, Machado-Domenech EE.
    Journal: Cell Mol Biol (Noisy-le-grand); 1996 Sep; 42(6):859-64. PubMed ID: 8891353.
    Abstract:
    A synthetic peptide corresponding to residues 1 to 40 of chicken alpha D-globin stimulated the accumulation of inositol phosphates (InsPs) in Trypanosoma cruzi epimastigotes. This accumulation was shown to be biphasic and dose-dependent. The enhanced inositol trisphosphate (InsP3) accumulation occurred at the third minute with a subsequent increase which is not transient, but sustained over a much longer period. Another peptide carrying residues 35 to 73 was less active. These results evidenced the activation of the phosphoinositide phospholipase C activity in response to peptides that bind specifically to T. cruzi epimastigote cells.
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