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  • Title: In vitro activity of trovafloxacin in combination with ceftazidime, meropenem, and amikacin.
    Author: Milatovic D, Wallrauch C.
    Journal: Eur J Clin Microbiol Infect Dis; 1996 Aug; 15(8):688-93. PubMed ID: 8894583.
    Abstract:
    The in vitro activity of trovafloxacin alone and in combination with ceftazidime, meropenem, and amikacin was studied by determining the minimal inhibitory concentrations (MICs) for 111 gram-negative and 71 gram-positive bacteria. In addition, the synergy of these combinations against 46 strains of gram-negative and gram-positive organisms was studied by checkerboard titration and time-kill kinetics. Trovafloxacin exhibited excellent in vitro activity against all strains tested. Synergism was observed in 17% of the gram-negative strains and in 32% of the gram-positive strains. No antagonism was observed with any of the combinations tested.
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