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  • Title: Alprazolam premedication and 35% carbon dioxide vulnerability in panic patients.
    Author: Pols H, Verburg K, Hauzer R, Meijer J, Griez E.
    Journal: Biol Psychiatry; 1996 Nov 01; 40(9):913-7. PubMed ID: 8896779.
    Abstract:
    A group of 20 patients who met the DSM-III-R criteria for panic disorder with or without agoraphobia underwent a 35% carbon dioxide (CO2) challenge after either 1 mg alprazolam or placebo in a double-blind, randomized, cross-over design. Despite the anxiolytic potential of alprazolam, it produced no significant effects on CO2-induced anxiety and panic symptomatology when compared to placebo.
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