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  • Title: L-NNA-sensitive regional cerebral blood flow augmentation during hypercapnia in type III NOS mutant mice.
    Author: Ma J, Meng W, Ayata C, Huang PL, Fishman MC, Moskowitz MA.
    Journal: Am J Physiol; 1996 Oct; 271(4 Pt 2):H1717-9. PubMed ID: 8897969.
    Abstract:
    The effect of NG-nitro-L-arginine (L-NNA) on regional cerebral blood flow (rCBF) response to hypercapnia (5% CO2 inhalation) was studied in urethan-anesthetized wild-type (SV-129) and type III nitric oxide (NO) synthase (NOS)-deficient mice, using laser-Doppler flowmetry and the closed cranial window technique. Resting rCBF during normocapnia decreased by approximately 25% after L-NNA superfusion in wild-type mice only (n = 18), suggesting a role for type III NOS in baseline blood flow. Hypercapnia augmented rCBF approximately 50% in both wild-type and type III NOS mutant mice. L-NNA superfusion (1 mM) inhibited this increase by approximately 60% in both strains. Hence, synthesis of NO by the constitutively expressed type I NOS contributes to blood flow augmentation during hypercapnia.
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