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  • Title: Persistence of high virus neutralizing antibody titers in cats experimentally infected with feline immunodeficiency virus.
    Author: Inoshima Y, Ikeda Y, Kohmoto M, Pecoraro MR, Shimojima M, Shimojima Y, Inada G, Kawaguchi Y, Tomonaga K, Miyazawa T, Mikami T.
    Journal: J Vet Med Sci; 1996 Sep; 58(9):925-7. PubMed ID: 8898296.
    Abstract:
    The development of virus neutralizing (VN) antibody is one of the most effective host defense mechanisms against virus infection. In the present study, we developed a new VN assay against feline immunodeficiency virus (FIV) using a feline T-lymphoblastoid cell line, MYA-1 cells, based on inhibition of viral reverse transcriptase production. This assay is applicable to strains of FIV which can not infect CRFK cells. By using the assay, we examined long-term responses of VN antibody in cats experimentally infected with FIV. VN antibody titers increased progressively during first 30 weeks post inoculation and remained at high titers thereafter for 7 years of observation periods.
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