These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Changes in phospholipid composition in rat liver microsomes and mitochondria under chemical carcinogenesis].
    Author: Poliakov VM, Lankin VZ.
    Journal: Biokhimiia; 1977 May; 42(5):799-808. PubMed ID: 889961.
    Abstract:
    Considerable change in phospholipid composition of microsomal and mitochondrial rat liver membranes under 3,4-benzpyrene-induced cancerogenesis is observed. The content of main phospholipid fractions (phosphatidylethanolamines and phosphatidylcholines) in rat liver microsomes increases at precancer stage and decreases during the tumour growth. On the contrary, the content of these phospholipids in mitochondrias decreases at precancer stage and increases at the period of vigerous tumour growth. The content of phosphatidylserines in rat liver microsomes sharply increases during the tumour growth, while in mitochondrias in decreases to an extremely low concentration beginning from early cancerogenesis stages. Lysophosphatides content in rat liver microsomes considerably increases under cancerogenesis. The noticeable amount of characteristic microsomal phospholipids, sphingomyelins, appears in rat liver mitochondrias under the growth of induced tumours. The peroxides of phosphatidylethanolamines and phosphatidylcholines appear in rat liver mitochondrias at later cancerogenesis stages, as compared with microsomes.
    [Abstract] [Full Text] [Related] [New Search]