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  • Title: [Isolation and properties of Micrococcus luteus endonucleas acting in DNA depurinization but inactive with pyrimidine dimers].
    Author: Tomilin NV, Barenfel'd LS.
    Journal: Biokhimiia; 1977 Jun; 42(6):985-93. PubMed ID: 889977.
    Abstract:
    An endonuclease (AP-endonuclease II) that specifically attacks double stranded or single stranded depurinated DNA, resulting in single-strand nicks, has been purified 320-fold from Micrococcus luteus. The enzyme is not stimulated by 0.002 M MgCl2, it induces 3'OH-5'PO4 breaks on the 5' side of apurinic sites, it has no activity towards UV-irradiated DNA and has a molecular weight of about 30 000. In cooperation with DNA-polymerase from M. luteus and T4 DNA ligase, AP-endonuclease II has been shown capable of carrying out complete excision repair of depurinated DNA in vitro.
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