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  • Title: Inhibitory influence of lung vagal C-fiber afferents on the delayed ventilatory response to inhaled wood smoke in rats.
    Author: Wang CY, Lai CJ, Kou YR.
    Journal: Chin J Physiol; 1996; 39(1):15-22. PubMed ID: 8902300.
    Abstract:
    We studied the influences of lung vagal afferents on the delayed ventilatory response to inhaled wood smoke in 35 Sprague-Dawley rats. Wood smoke (approximately 6 ml) was inhaled via tracheostomy when animals breathed spontaneously. Immediately after inhalation, wood smoke evoked a slowing of respiration or an augmented inspiration, followed by a delayed tachypnea. Owing to the increase in respiratory frequency, the delayed ventilatory response usually resulted in an increase in minute ventilation (VI). The smoke-induced increase in VI was elevated after perineural capsaicin treatment of both cervical vagi (PCT, n = 12), but was unaltered during cooling of both vagi to 6.7 degrees C (VGC, n = 9); PCT selectively blocked the conduction of unmyelinated C-fibers, whereas VGC differentially blocked the conduction of myelinated fibers. Furthermore, the smoke-induced increase in VI after PCT was unaffected by an additional application of VGC (n = 12), whereas it was magnified by an additional application of PCT during VGC (n = 9). This magnification was not changed after a subsequent bilateral vagotomy (n = 21). Removal of smoke particulates did not affect the increase in VI evoked by smoke inhalation (n = 14). These results suggest that 1) the smoke-induced delayed ventilatory response is restrained by the inhibitory input from lung vagal C-fibers, whereas it was not influenced by the input from irritant receptors and 2) the gas phase of wood smoke is responsible for eliciting this delayed ventilatory response.
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