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  • Title: LITTLE KEVIN: a program for the estimation of protein homology by analysing the amino acid compositions and sequences.
    Author: Grillasca JP, Aubert D, Planells R, Domingo N, Lafont H.
    Journal: Comput Appl Biosci; 1996 Aug; 12(4):347-51. PubMed ID: 8902361.
    Abstract:
    We present here a computational method based on the analysis of amino acid composition for performing comparisons between proteins. This user-friendly and reliable test is aimed at rapidly identifying, from data-base subsets, sequences--if necessary, partial sequences--which share similar amino acid compositions to the input composition (deduced from experimental results). Apparent molecular weight (as determined by SDS-PAGE) and artefactual modifications due to the experimental determination of the amino acid composition are taken into account to perform the comparison. This program thus constitutes a useful tool in searching for the probable identification of either non-sequenced proteins or peptides from hydrolysed proteins.
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