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  • Title: Modulation by locally produced luminal angiotensin II of proximal tubular sodium reabsorption via an AT1 receptor.
    Author: Hiranyachattada S, Harris PJ.
    Journal: Br J Pharmacol; 1996 Oct; 119(4):617-8. PubMed ID: 8904632.
    Abstract:
    The concentration of angiotensin II reported in proximal tubular fluid in anaesthetized rats is considerably higher than in plasma, indicating secretion of this peptide into the tubular lumen. Shrinking split-drop micropuncture was used to examine the effect of endogenous angiotensin on sodium and water absorption in the proximal convoluted tubule. Addition of losartan, a nonpeptide AT1 receptor blocker, to intratubular fluid increased fluid uptake by 15.7 +/- 3.9% (10(-5) M) and 24.7 +/- 9.4% (10(-4) M) whereas the AT2 inhibitor, PD123319 had no effect. We conclude that angiotensin II is secreted into proximal tubular fluid and, in the anaesthetized rat, is maintained at a concentration that inhibits sodium and water transport via AT1 receptors.
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