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  • Title: 4-(3,4-Dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline derivatives. II. Their renal vasodilation activity and structure-activity relationship.
    Author: Anan H, Tanaka A, Tsuzuki R, Yokota M, Yatsu T, Fujikura T.
    Journal: Chem Pharm Bull (Tokyo); 1996 Oct; 44(10):1865-70. PubMed ID: 8904813.
    Abstract:
    A series of 4-(3,4-dihydroxyphenyl)-1,2,3,4-tetrahydroisoquinoline derivatives showed potent DA1 agonistic activities. We investigated the structure-activity relationship of the racemic compounds of this series. 4-(3,4-Dihydroxyphenyl)-7-methanesulfonamido-1,2,3,4-tetrahydroiso quinoline (43) was identified as a potent renal vasodilator with activity almost equal to that of YM435 (1).
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