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  • Title: Isolation and structure of hemibastadinols 1-3 from the Papua New Guinea marine sponge Ianthella basta.
    Author: Pettit GR, Butler MS, Williams MD, Filiatrault MJ, Pettit RK.
    Journal: J Nat Prod; 1996 Oct; 59(10):927-34. PubMed ID: 8904842.
    Abstract:
    Further investigation of the Bismarck Archipelago (Papua New Guinea) marine sponge Ianthella basta for biologically active constituents has led to the isolation of hemibastadins 1 (2), 2 (3), and 3 (4) and the new brominated tyrosine derivatives hemibastadinols 1-3 (9, 13, and 14). Isolation and structure elucidation of the monomethyl ether derivatives (7 and 8) of hemibastadins 1 and 2 and the 3-bromotyramine amide of oxalic acid amide (1a) concluded our chemical investigation of I. basta. The hemibastadins and hemibastadinols represent important biosynthetic links to a series of bromotyrosine tetramers collectively known as the bastadins. The antimicrobial activity of the bastadins, hemibastadins, and hemibastadinols is summarized.
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