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  • Title: EBV-specific cytotoxic T lymphocytes protect against human EBV-associated lymphoma in scid mice.
    Author: Buchsbaum RJ, Fabry JA, Lieberman J.
    Journal: Immunol Lett; 1996 Sep; 52(2-3):145-52. PubMed ID: 8905410.
    Abstract:
    Scid mice develop human EBV-positive B cell tumors after injection with EBV-transformed human B cells or peripheral blood lymphocytes from EBV-seropositive donors. Injection of cytotoxic T cell (CTL) lines, selectively expanded in vitro to recognize autologous EBV-transformed B cells, protected mice against developing human lymphoproliferative disease. CTL protection required a single dose of polyethylene-glycol-conjugated IL2. Mice were not protected by CTL that did not specifically recognize EBV-transformed B cells or by mitogen-activated lymphocytes.
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