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  • Title: In vitro and in vivo characterization of a 99mTc complex with tris(hydroxymethyl)phosphine (THP).
    Author: Berning DE, Katti KV, Singh PR, Higgenbotham C, Reddy VS, Volkert WA.
    Journal: Nucl Med Biol; 1996 Jul; 23(5):617-22. PubMed ID: 8905826.
    Abstract:
    The water-soluble, monophosphine ligand tris(hydroxymethyl)phosphine (THMP) was complexed with 99mTc. The 99mTc-THMP was formed in high radiochemical purity by simply mixing 99mTcO4- with THMP over a wide pH range. In vitro and in vivo studies indicated the complex to be highly stable under the respective conditions. HPLC analysis indicated a singular species with a retention time identical to the known [ReO2(THMP)4]1 complex. Results show that the hydroxymethylphosphine functionality is attractive for use in designing new 99mTc radiopharmaceuticals.
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