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  • Title: Acute lethality of D- and L-ethionine in Swiss mice.
    Author: Friedman MA, Berry DE, Elzay RP.
    Journal: Cancer Lett; 1977 Jul; 3(1-2):71-6. PubMed ID: 890687.
    Abstract:
    The acute, 7-day LD50 in Swiss mice of D-ethionine administered intraperitoneally, was determined as 185 mg/kg with 95% confidence limits of 163 and 210 mg/kg. L-ethionine, the stereoisomer, which is more potent in inhibiting liver RNA synthesis, was not lethal at 2500 mg/kg. This acute toxicity of D-ethionine was suppressed by L-methionine and adenine. Blood accumulation in the thoracic cavity and pericardium was the probable cause of death.
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