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  • Title: Uptake of labeled dianhydrogalactitol into human gliomas and nervous tissue.
    Author: Eckhardt S, Csetényi J, Horváth IP, Kerpel-Fronius S, Számel I, Institóris L, Szlovik F, Pásztor E, Afra D.
    Journal: Cancer Treat Rep; 1977 Aug; 61(5):841-7. PubMed ID: 890693.
    Abstract:
    The distribution of iv administered 3H-dianhydrogalactitol (DAG) in the plasma, cerebrospinal fluid (CSF), brain, and tumor tissue was studied in 11 patients. DAG entered the CSF and was slowly eliminated, with a half-life of 20 hours. Unchanged DAG accounted for about 6%-30% of the total radioactivity in the CSF. All the tumors accumulated the drug to a higher extent than the intact white matter, except the one meningioma studied. The highest uptake was observed in the relatively benign astrocytic tumors.
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