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  • Title: [The immunity status of pulmonary tuberculosis patients excreting drug-resistant Mycobacterium tuberculosis].
    Author: Chukanov VI, Kuz'mina NV.
    Journal: Probl Tuberk; 1996; (1):17-9. PubMed ID: 8907476.
    Abstract:
    Spontaneous rosette formation with sheep red cells, lymphocyte blast-transformation in the presence of PHA and PPD, estimation of cells carrying CD3+, CD4+, CD8+, EKK-antigens were studied in 208 HIV-negative adult patients with destructive tuberculosis of the lungs. The sputum from 87 of them contained M. tuberculosis sensitive to antituberculous drugs. M. tuberculosis from 121 of them were resistant to drugs. It was found that patients discharging drug-resistant M. tuberculosis had significantly more frequent suppression of T-cell immunity than patients whose M. tuberculosis were sensitive to chemotherapy.
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