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  • Title: No proof of HTLV-I/II in intravenous drug abusers with a high rate of HIV-1 infection in central Thailand.
    Author: Saguanwongse S, Muangpom A, Ruchusatsawat N, Wongcheree S, Warachit P, Miyamura K, Yamazaki S, Honda M.
    Journal: Microbiol Immunol; 1996; 40(9):639-44. PubMed ID: 8908608.
    Abstract:
    Serum specimens of 1,074 intravenous drug abusers (IVDA) were examined for infection with HIV-1, HTLV-I and HTLV-II in central Thailand. Three hundred and sixty-two of the specimens were seropositive for HIV-1 (33.7%). The HIV-1 seropositive IVDAs exhibited increased seropositivity with age through group 40-44 and significantly decreased seropositivity over the age of 45. In contrast, no seropositivity to either HTLV-I or -II was detected in the samples tested by a particle-agglutination assay for HTLV followed by type-specific Western blotting for HTLV. Reference to previous reports suggested that the rate of HIV infection in IVDAs has decreased with no HTLV-I or HTLV-II in Thailand when compared with that of the HIV infection in 1992. A major HIV-1 epidemic took off in Thailand in 1988 and spread throughout the country. Blood serum samples from 1036 male and 38 female IV drug users at Thanyarak Narcotics Hospital in Pathurmthani, Bangkok, in January 1995 were examined for infection with HIV-1, HTLV-I and HTLV-II. 362 specimens (33.7%) were HIV-1-seropositive, 49% of whom were 25-34 years old. At ages 45 years and older, the level of HIV seropositivity was significantly lower. No seropositivity of either HTLV-I or HTLV-II was detected in the samples tested by particle-agglutination assay for HTLV followed by type-specific Western blotting for HTLV. The identified level of HIV seroprevalence in this study population is lower than the 1992 level and the 38% determined in 1994 among IV drug users at the hospital. No other population in Thailand has been found to have an increased prevalence of HIV-1 infection. These findings suggest that HIV-1 infection in Thailand may be quite widely spread with prevalence decreasing only among IV drug users.
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