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  • Title: Inhibitory effect of caffeine on the response to carbachol in rat pancreatic acini.
    Author: Grosflis K, Métioui M, Lenoble S, Dehaye JP.
    Journal: Gen Pharmacol; 1996 Sep; 27(6):1041-6. PubMed ID: 8909988.
    Abstract:
    1. Caffeine did not affect by itself the amylase release, nor intracellular calcium concentration in rat pancreatic acini. 2. Concentration of caffeine higher than 1 mM inhibited the amylase released in response to the muscarinic agonist carbamylcholine. This inhibition was also seen on the intracellular calcium elevation: 20 mM caffeine inhibited by 80% the calcium elevation in response to 100 microM carbachol. 3. Caffeine also prevented the specific binding of [3H]-N-methylscopolamine ([3H]-NMS) on rat pancreatic muscarinic receptors. 4. We conclude that caffeine behaves as a muscarinic antagonist.
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