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  • Title: The role of adrenocortical steroid hormones in the development of hearing.
    Author: Freeman S, Geal-Dor M, Sohmer H.
    Journal: J Basic Clin Physiol Pharmacol; 1996; 7(3):167-77. PubMed ID: 8910135.
    Abstract:
    Based on the findings that adrenocortical hormones are involved in the regulation of Na+, K(+)-ATPase in several tissues and the presence of receptors for these hormones in the ear during auditory development, it has been suggested that these hormones also induce Na+, K(+)-ATPase activity and the endocochlear potential in the ear, leading to auditory function in the fetus-neonate. In order to test this hypothesis, glucocorticoid and mineralocorticoid hormones were injected into rat pups and their auditory development, compared to control litter-mates, was tested by recording auditory nerve-brainstem evoked potentials (ABR). Those who received glucocorticoid hormones had elevated ABR thresholds on post-natal day (PND) 9, others on PND 11 and still others on PND 16, compared to control litter-mates. The ABR thresholds of those injected with mineralocorticoids were not different from those in controls. These results and additional considerations related to the time sequence of the natural appearance of these hormones in the plasma, of their receptors in the ear and the onset of hearing in rat pups makes it extremely unlikely that adrenocortical hormones are involved in the initiation of Na+, K(+)-ATPase pumps and thereby of the endocochlear potential in the inner ear. It is possible that these hormones and their receptors play a role in the later regulation of the number of pumps.
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