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  • Title: Sterility: an immunologic disorder?
    Author: Rümke P, Hekman A.
    Journal: Clin Obstet Gynecol; 1977 Sep; 20(3):691-703. PubMed ID: 891061.
    Abstract:
    Immunologic aspects of infertility are discussed. The autoantigenic and isoantigenic nature of spermatozoa is reviewed. Sperm antibodies may form in males by extravasation of spermatozoa following vasectomy and as a result of testicular lesions. Although little is known about the formation of isoantibidies to spermatozoa in females, they may arise as a result of epithelial lesions of the genital tract. Clinical findings of sperm agglutination and immobilizing antibodies in males and sperm antibodies in females in association with infertility are discussed along with some therapeutic approaches. A rare condition, allergy to seminal plasma, is noted.
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