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  • Title: Study of medroxyprogesterone acetate and testosterone enanthate as a male contraceptive.
    Author: Brenner PF, Mishell DR, Bernstein GS, Ortiz A.
    Journal: Contraception; 1977 Jun; 15(6):679-91. PubMed ID: 891194.
    Abstract:
    The effect of im injections of medroxyprogesterone acetate (100 or 150 mg) and testosterone enanthate (200 mg) over a 4-month period on spermatogenesis and serum testosterone levels was studied in 14 healthy, normal men. Treatment reduced sperm counts and suppressed gonadotropin levels in all subjects. 10 subjects showed sperm counts of less than 5 million/ml, though only 2 became azoospermic. A return to pretreatment sperm concentrations was not observed until 16-41 weeks after the last injection. Testosterone enanthate did not maintain serum testosterone levels at pretreatment values, though none of the subjects reported a decrease in libido. 1 subject developed unilateral gynecostamia during treatment. It is concluded that the doses used in this study are probably insufficient to provide effective contraception in males.
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