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  • Title: Sometimes a great motion: the application of transient electric birefringence to the study of macromolecular structure.
    Author: Hagerman PJ.
    Journal: Curr Opin Struct Biol; 1996 Oct; 6(5):643-9. PubMed ID: 8913687.
    Abstract:
    First described in the late 1800s, the phenomenon of electric birefringence is becoming increasingly useful as a probe of the solution conformations of proteins and nucleic acids. The birefringence response to a transient electric field is a sensitive indicator of the rotational motions (and hence the physical dimensions) of macromolecules in solution. Recent advances, both in instrumentation and in the efficient production of high-quality biopolymers, have dramatically increased the sensitivity and range of applicability of the method.
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