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  • Title: Detection of IgA against the mycobacterial antigen A60 in serum and saliva in patients with active pulmonary tuberculosis: preliminary results.
    Author: Del Pezzo M, Alifano M, Faraone S, Battiloro R, De Pascalis R, Lavitola A.
    Journal: New Microbiol; 1996 Oct; 19(4):363-7. PubMed ID: 8914139.
    Abstract:
    Humoral immune response against the mycobacterial antigen A60 was evaluated in 38 subjects: 13 healthy volunteers (Group I), 10 patients with a defined acute or chronic non tuberculous lung disease (Group II), 15 patients suffering from pulmonary tuberculosis (Group III). Saliva IgA in samples diluted in various concentrations (1:10, 1:30, 1:50) and serum IgG and IgA levels were measured by ELISA. Positive values of IgG were found in sera of 0/13 subjects from Group I, 1/10 from Group II, 12/15 from Group III; searching for IgA in serum was positive in 1/13 subjects from Group I, 2/10 from Group II, 11/15 from Group III, 1:30 dilution of saliva led to positive results in 0/13 subjects from Group I, 0/10 from Group II and 10/15 from Group III. The measurement of anti-A60 IgA levels in both saliva and serum might be a useful complement to serology based on detection of anti-A60 IgG in blood samples.
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