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  • Title: Serum antibody responses of foals to virulence-associated 15- to 17-kilodalton antigens of Rhodococcus equi.
    Author: Tákai S, Hidaka D, Fujii M, Shindoh Y, Murata T, Nakanishi S, Sasaki Y, Tsubaki S, Kamada M.
    Journal: Vet Microbiol; 1996 Sep; 52(1-2):63-71. PubMed ID: 8914251.
    Abstract:
    Humoral immune responses in 16 foals to virulence-associated 15- to 17-kDa antigens of Rhodococcus equi were studied during the first fourteen weeks of life on two horse-breeding farms with a persistent incidence of R. equi infection. Serum antibody levels specific for 15- to 17-kDa antigens were measured by enzyme-linked immunosorbent assay and Western immunoblotting. Immunoglobulin G (IgG) antibodies specific to 15- to 17-kDa antigens were detected by all the foals. R. equi was found in the feces of foals during week 1 of life, and the number of fecal R. equi rapidly increased to the highest level. Virulent R. equi were isolated from the feces of the foals at a high frequency and from their environmental soil on the farms. Evidence that serum antibody response to 15- to 17-kDa antigens of virulent R. equi occurred naturally in every foal in correlation with the quantitative changes of fecal R. equi during the first 1 to 3 months of life suggests that intestinal virulent R. equi might be the most important source of antigenic stimulation in foals from contaminated farms.
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