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  • Title: Beneficial effect of granulocyte-colony stimulating factor in scleromyxoedema associated with severe idiopathic neutropenia.
    Author: Cohen AM, Hodak E, David M, Mittelman M, Gal R, Stern R.
    Journal: Br J Dermatol; 1996 Oct; 135(4):626-9. PubMed ID: 8915161.
    Abstract:
    The treatment of scleromyxoedema is notoriously difficult. We present a patient with long-standing diffuse scleromyxoedema associated with functional impairment who developed chronic idiopathic neutropenia complicated by recurrent life-threatening infections. Treatment with recombinant granulocyte--colony stimulating factor led to normalization of the neutrophil count, prevented further systemic infections, and unexpectedly was associated with a striking clinical improvement of her skin disorder and decrease in mucin deposition in the dermis.
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