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  • Title: Antagonistic effects of atipamezole on medetomidine-induced sedation in horses.
    Author: Yamashita K, Yonezawa K, Izumisawa Y, Kotani T.
    Journal: J Vet Med Sci; 1996 Oct; 58(10):1049-52. PubMed ID: 8916013.
    Abstract:
    The antagonistic effects of atipamezole (20, 40, 60, 80, and 100 micrograms/kg i.v.) on medetomidine (10 micrograms/kg i.v.)-induced sedation were evaluated in horses. Although 20 and 40 micrograms/kg of atipamezole were not sufficient to reverse the sedation, 60 micrograms/kg did effectively reverse the sedation. Atipamezole at 80 micrograms/kg was more potent, and significantly shortened the duration of sedation without any apparent side effects, but a higher dose of 100 micrograms/kg was not more effective than 80 micrograms/kg. The possible use of atipamezole as a reversal agent may enhance the value and availability of medetomidine as a chemical restraint agent in horses.
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