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  • Title: Effects of amphetamine on brain biogenic amines in isolated and aggregated rats.
    Author: Lokiec F, Jacquot C, Rapin JR, Cohen Y.
    Journal: Eur J Pharmacol; 1977 Aug 15; 44(4):391-5. PubMed ID: 891613.
    Abstract:
    d- and 1-amphetamine were injected (15 mg/kg i.p.) into isolated or aggregated rats. Both d- and 1-forms decreased the noradrenaline levels of brain areas in isolated and in aggregated rats. d-Amphetamine decreased 5-hydroxytryptamine (5-HT) and 5-hydroxyindolacetic acid (5-hiaa) levels in aggregated rats only. 1-Amphetamine induced no change in 5-HT and 5-HIAA levels. The greater sensitivity of aggregated rats to d-amphetamine can be ascribed to a change in 5-HT metabolism rather than to a modification of noradrenaline levels.
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