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  • Title: Treatment of HCV liver disease by recombinant interferon alpha.
    Author: Bailly F, Si N, Si A, Trepo C.
    Journal: Nephrol Dial Transplant; 1996; 11 Suppl 4():56-7. PubMed ID: 8918757.
    Abstract:
    Interferon alpha has confirmed its efficacy for the therapy of chronic hepatitis C. Half of the patients treated will normalize their plasma ALT at the end of a 6-month course of 3 MU thrice a week. This biochemical response is associated with a reduction of HCV RNA (viraemia) from serum and with significant improvement of liver histology. Despite those beneficial effects, 50% of treatment responders generally relapse after treatment arrest. Increasing doses to 6 MU and/or the duration of interferon therapy increases the proportion of long-term sustained responders. Combining therapy with ribavirin, a nucleoside analogue, also appears to have a similar effect.
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