These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Mutation of the mismatch repair genes for carcinogenesis of sporadic colorectal cancers with RER-positive phenotype].
    Author: Sasaki S, Nakamura Y.
    Journal: Nihon Rinsho; 1996 Apr; 54(4):1008-13. PubMed ID: 8920665.
    Abstract:
    Genetic instability, monitored by (a) replication error, is a feature of many hereditary and sporadic colorectal cancers. When such tumors are familial, the genetic instability is thought to be triggered by inherited mutations in DNA-mismatch repair genes but the mechanism by which sporadic tumors exhibit RER+ phenotypes is not as well understood. We examined RER in 129 sporadic colorectal tumors. In eight of them that exhibited RER+ at two or more loci, we screened for mutations of hMLH1 and hMSH2. We detected only two mutations; one was a constitutional mutation of hMLH1 and the other was a somatic mutation of hMSH2. These results suggest that RER in sporadic tumors does not always reflect germline mutation in genes associated with mismatch repair.
    [Abstract] [Full Text] [Related] [New Search]