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  • Title: [Gastric proton pump: genes and their expression].
    Author: Futai M.
    Journal: Nihon Rinsho; 1996 Apr; 54(4):1138-43. PubMed ID: 8920687.
    Abstract:
    The gastric proton pump (H+/K(+)-ATPase) is a typical P-type ATPase consisting of the alpha and beta subunits and secreting acid into stomach. This enzyme is similar to Na+/K(+)-ATPase in primary structure and gene organization. The exon/intron organizations of the genes for the two subunits of H+/K(+)-ATPase are highly similar to those of the corresponding subunits of Na+/K(+)-ATPase. In contrast to Na+/K(+)-ATPase subunits, alpha and beta subunits of H+/K(+)-ATPase are expressed specifically in gastric parietal cells. Consistently, a sequence motif [(G/C)PuPu(G/C)NGAT(A/T)PuPy] in the 5'upstream regions of the H+/K(+)-ATPase subunit genes was recognized by the gastric mucosal nuclear protein(s). We found that two novel zinc-finger proteins (GATA-GT1 and GATA-GT2) are present in the gastric parietal cells and bind to this motif. These proteins activate the transcription of the reporter gene connected with the 5'-upstream regions of the H+/K(+)-ATPase subunit genes. These results suggest that gastric GATA-DNA binding proteins have roles in activating transcription of H+/K(+)-ATPase genes in parietal cells.
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