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  • Title: Detection of nitrosyl complexes in human substantia nigra, in relation to Parkinson's disease.
    Author: Shergill JK, Cammack R, Cooper CE, Cooper JM, Mann VM, Schapira AH.
    Journal: Biochem Biophys Res Commun; 1996 Nov 12; 228(2):298-305. PubMed ID: 8920909.
    Abstract:
    Idiopathic Parkinson's disease (PD) involves a documentable decline in the activity of mitochondrial complex I in substantia nigra (1-3). We have EPR spectroscopy to investigate complex I in human substantia nigra and globus pallidus. EPR signals characteristic of the iron-sulfur centers of complexes I and II were observed with globus pallidus, with no significant difference between control and PD. These complex 1 signals could not be clearly observed in substantia nigra. Instead, nitric oxide (NO.) radicals in PD nigra were detected at g approximately 2.08, 1.98 due to [haem-NO] formation. Although an EPR signal indicative of haem-NO was observed with control nigra, it lacked the distinctive g approximately 1.98 trough observed with PD nigra. As PD is associated with a reactive gliosis, the difference in the haem-NO EPR signal, between control and PD nigra, may result from cytotoxic NO. generated by microglia in PD substantia nigra.
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