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  • Title: Inhibition of spontaneous transformation of rat embryo cells releasing endogenous type C virus by virus-specific antiserum.
    Author: Rasheed S, Young H, Gardner MB.
    Journal: J Natl Cancer Inst; 1979 Sep; 63(3):745-50. PubMed ID: 89211.
    Abstract:
    Noninbred Sprague-Dawley rat embryo cell clones predictably undergo transformation after 20-30 in vitro passages following spontaneous release of endogenous rat leukemia virus (RaLV). In the presence of RaLV-specific antiserum, virus production and infectivity were reduced and transformation was delayed from 6 to 25 weeks. Transformation was not associated with an increased expression of Kirsten murine sarcoma virus-related src gene RNA.
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