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  • Title: The DNA polymerase-encoding gene from a thermoacidophilic archaeon Sulfolobus acidocaldarius.
    Author: Datukishvili N, Pokholok D, Lottspeich F, Prangishvili D, Rechinsky V.
    Journal: Gene; 1996 Oct 24; 177(1-2):271-3. PubMed ID: 8921881.
    Abstract:
    We have cloned, sequenced and characterized the gene encoding a DNA polymerase from the thermoacidophilic archaeon Sulfolobus acidocaldarius (Sac). The putative transcription promoter and terminator elements, as well as a potential ribosome-binding site (rbs), have been identified in the flanking regions. One large open reading frame (ORF) found in the sequenced portion of the Sac genome encodes a protein of 875 amino acids (aa). All conserved motifs characteristic of family B of DNA polymerases have been found in the deduced primary structure of this enzyme. The Sac DNA polymerase also contains sequence motifs that form a proofreading exonuclease domain.
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