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  • Title: HLA-B5 associated with duodenal ulcer.
    Author: Rotter JI, Rimoin DL, Gursky JM, Terasaki P, Sturdevant RA.
    Journal: Gastroenterology; 1977 Sep; 73(3):438-40. PubMed ID: 892338.
    Abstract:
    In a search for further genetic factors contributing to ulcer disease we undertook a study of the frequency of HLA antigens in patients with duodenal ulcer. Seventy-seven male patients (of two races) were typed for the HLA-A and-B loci. Thirteen of the 54 (24%) white males were found to have antigen B5 compared to 10% of controls. These results have a P value of 0.0016 which remains significant even when multiplied by the number of antigens tested (28). These results demonstrate a significant association between duodenal ulcer and HLA antigen B5 in white males, with a relative risk of 2.9, greater than that associated with the combination of blood group O and nonsecretor status.
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