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  • Title: Gastric acid secretion in gastric fistula dogs after antral denervation and antrectomy.
    Author: Trout HH, Elashoff J, Harmon JW.
    Journal: Gastroenterology; 1977 Sep; 73(3):492-4. PubMed ID: 892347.
    Abstract:
    Acid secretion in Pavlov pouches in dogs is known to increase after antrectomy in response to histamine and gastrin. Dogs with gastric fistulae were tested with histamine and tetragastrin as a control study. The vagal nerve fibers to the antrum were divided and the dogs underwent repeat testing. Finally an antrectomy was performed and final dose-response data were collected. After antrectomy there was an increased acid response to histamine and tetragastrin. We postulate that the vagal fibers innervating the antrum are probably not a factor in this increase. Furthermore, we believe that the increased acid secretion after antrectomy observed in the dog and the decrease known to occur in the human being is a species difference and is not related to the pouch method of study used in earlier studies of the antrectomized dog.
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