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  • Title: Quantitation of a new potent angiotensin II receptor antagonist, TCV-116, and its metabolites in human serum and urine.
    Author: Miyabayashi T, Okuda T, Motohashi M, Izawa K, Yashiki T.
    Journal: J Chromatogr B Biomed Appl; 1996 Feb 23; 677(1):123-32. PubMed ID: 8925084.
    Abstract:
    A sensitive high-performance liquid chromatographic (HPLC) method is described for the determination of a new potent antihypertensive agent, TCV-116, and its two metabolites (M-I and M-II) in human serum or urine. After pre-treatment of the specimens, the analytes were determined using a column switching technique, except for the metabolites in urine which were determined by gradient elution mode HPLC. The quantitation limits for TCV-116, M-I and M-II were all 0.5 ng/ml in serum, and 0.5, 10 and 110 ng/ml in urine, respectively. The methods were applied to clinical trials of TCV-116.
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