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  • Title: Met-enkephalin induces cytolytic processes of apoptotic type in K562 human erythroid leukemia cells.
    Author: Mernenko OA, Blishchenko EY, Mirkina II, Karelin AA.
    Journal: FEBS Lett; 1996 Apr 01; 383(3):230-2. PubMed ID: 8925902.
    Abstract:
    Cytolytic activity of Met-enkephalin, an endogenous opioid peptide, was studied within the 10(-7)-10(-17) M concentration range in K562 human erythroid leukemia cells. Cytolytic activity was determined by the trypan blue inclusion method after 13, 15 and 18 h of Met-enkephalin co-incubation with target cells. Discrete maxima of cytolytic activity were detected at concentrations of 10(-9)-10(-10), 10(-13) and 10(-15) M. Cytolysis was accompanied by internucleosomal DNA fragmentation which is indicative of the mechanism of cell death being apoptosis.
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