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  • Title: SNAP-25 is present on chromaffin granules and acts as a SNAP receptor.
    Author: Tagaya M, Genma T, Yamamoto A, Kozaki S, Mizushima S.
    Journal: FEBS Lett; 1996 Sep 23; 394(1):83-6. PubMed ID: 8925933.
    Abstract:
    SNAP-25 is located on the plasma membrane and essential for exocytosis of neurotransmitters. It was suggested that SNAP-25 and syntaxin 1 via the interaction with VAMP-2 located on synaptic vesicles mediate the docking of the vesicles with the plasma membrane. In the present study, by means of biochemical and morphological analyses, we showed that SNAP-25 is present on chromaffin granules as well as on the plasma membrane. Reconstitution and immunoprecipitation analyses revealed that SNAP-25 on chromaffin granules has essentially the same properties as does SNAP-25 on the plasma membrane.
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