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  • Title: [Thrombolytic therapy in acute lower extremity ischemia].
    Author: Rørdam P, Enevoldsen MT, Grønvall Rasmussen JB, Laursen NO, Hensler MK, Madsen PV, Schroeder TV.
    Journal: Ugeskr Laeger; 1996 Sep 02; 158(36):5018-21. PubMed ID: 8928240.
    Abstract:
    During a period of four and a half years 37 lower extremities with acute ischaemia were treated with thrombolysis. Angiographically, 35 cases demonstrated no suitable arteries for distal reconstruction. In two cases vascular surgery was not performed because of cardiac incompensation. Two patients died within one month and limb salvage was 69%. During 22 months (3-48) of follow-up another six patients were amputated two to nine months later. The 18 salvaged lower extremities (49%) had an ankle-brachial pressure index of 0.63 (0.30-1.-09). Review of all angiograms revealed a demonstrable effect of thrombolytic therapy only in 13 (35%) cases. In conclusion, thrombolytic therapy should be considered in the case of acute lower extremity ischaemia unsuitable for reconstructive procedures. Even though the effect of thrombolytic therapy cannot be demonstrated on the angiogram, that should not necessarily deem the treatment to be a failure.
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