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  • Title: Creatine phosphokinase-linked immunoglobulin associated with hypokalemic myopathy.
    Author: Hoshino J, Arai H, Fukusato T, Nakamura T, Nushiro N, Sato K, Sakamaki T, Murata K.
    Journal: Intern Med; 1995 Dec; 34(12):1210-4. PubMed ID: 8929653.
    Abstract:
    We present three women with hypokalemic myopathy in whom serum creatine phosphokinase (CPK) was bound to serum immunoglobulin (macro-CPK). In all three cases, CPK isozyme electrophoresis demonstrated an extra CPK band between CPK-MM and CPK-MB. The bound immunoglobulins were identified as IgA/A-kappa and lambda, IgA-lambda and IgA-kappa and lambda, respectively. In all cases, histological examination of the biopsied muscles revealed necrotic and/or regenerating fibers. In each patient, potassium replacement therapy returned the macro-CPK as well as the marked elevations of serum muscle enzymes to normal. Taken together with other recent reports, our findings suggested that CPK-immunoglobulin binding may be related to the emergence of pathophysiology of hypokalemic myopathy.
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