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  • Title: A role of Ca2+/calmodulin-dependent protein kinase II in the induction of long-term potentiation in hippocampal CA1 area.
    Author: Miyamoto E, Fukunaga K.
    Journal: Neurosci Res; 1996 Jan; 24(2):117-22. PubMed ID: 8929917.
    Abstract:
    Long-term potentiation (LTP) in the CA1 area of the hippocampus is considered to be a synaptic model for learning and memory. The induction of LTP is initiated by activation of the NMDA glutamate receptor in the postsynaptic membrane and a subsequent increase in Ca2+ -influx into the neurons following glutamate release. The action of Ca2+ has been proposed to be mediated by Ca2+ -dependent protein kinases. Recent studies indicate that, among the protein kinases, Ca2+/calmodulin-dependent protein kinase II is implicated in the induction of LTP in the hippocampus.
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